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Scientific Title: Development of an MHC Class I Tetramer to Study Virus- and Tumor-specific CD8+ T-cell Responses in Dogs

Dr. Paul R. Hess, North Carolina State University, D15CA-015

Summary: Researchers will develop a state-of-the art molecular tool to track and study killer T-cell populations that are responsible for fighting viral infections and cancer in dogs.

Description: In humans, a powerful immunologic reagent called a tetramer is standardly used to visualize changes in the body's killer T-cells.  These cells respond to immunologic challenges and are critical to the body's immune system.  Current knowledge of T-cell behavior in dogs could be significantly advanced with the development of a dog-specific tetramer.  Researchers will work to construct the first canine tetramer, which would then be used in the development of vaccines for infectious diseases and cancer in dogs.

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