Principal Investigator: Dr. Gary S. Johnson, DVM PhD; University of Missouri, Columbia
Total Grant Amount:  $84,121.00; Grant Period:  5/1/2016 - 10/31/2017

Epilepsy is one of the most common neurologic diseases of dogs and a top concern of dog breeders.  Despite strong evidence that genetics is important in determining the risk of idiopathic epilepsy, numerous gene mapping studies have failed to identify a locus that accounts for that risk in either dogs or humans. Seizures occur when excessive activity goes beyond the normal threshold for brain function, many factors contribute to that level of activity, and therefore, mutations in numerous genes may collectively contribute to increased activity until that threshold is exceeded, resulting in epilepsy. Any one of these mutations may be present in non-epileptic dogs, but because it only partially alters activity, it would not produce seizures. Therefore, traditional gene mapping studies might overlook that mutation. Using a novel whole genome sequencing approach the investigators hope to identify DNA variations in epileptic dogs that could affect the function of genes such as ion channels and neurotransmitter receptors that have been shown to alter the seizure threshold in humans or rodents. The frequency of such variations in populations of epileptic and non-epileptic dogs will be directly compared rather than the indirect markers used in traditional mapping studies. The increased power provided by looking for specific gene candidate variations rather than linked markers will aid the identification of epilepsy risk factors, perhaps leading to development of DNA tests to enable breeders to select against such risk factors.

AGSDCF Purpose

agsdcf_logo_smallThe American German Shepherd Dog Charitable Foundation, Inc. is a non-profit organization devoted to funding research projects that improve the health of the German Shepherd Dog.

We are grateful to the special dogs who have given their hearts and souls to make our daily lives happier. They ask nothing more than to be loved, fed, and their health needs met.

Your donations to this Foundation will help make future generations healthier and happier.



Contact us:

Welcome  |  What AGSDCF Does  |  How You Help  |  AGSDCF Organization  |  Links  |  Photos  |  Donations  |  Site Map

Copyright 2000-2017 by the American German Shepherd Dog Charitable Foundation, Inc.

RocketTheme Joomla Templates