CHFlogoGrant Amount: $12,960
Dr. Christine A Petersen, DVM PhD, University of Iowa
October 1, 2015 - September 30, 2016
Breed(s): All Dogs

Abstract
Recent studies show the presence of resistant infections in dogs and the ability of these infections to spread between a dog and its family. New treatment options are needed, and development of non-antibiotic antibacterial agents, or immunotherapy, is critical to progressing treatment for potentially fatal infections. This project will use cutting edge immunology to better understand how special regulatory immune cells (B10 B cells) in hunting Foxhounds with naturally-occurring Leishmania infections might be reprogrammed to help fight infections. These unique immune cells are thought to alter the course of human diseases such as malaria, lupus, and arthritis. Dogs have an immune system very similar to humans and, unlike mice, represent a way to investigate and further understand these cells in naturally-occurring infections in dogs; findings that will also translate to human health. This innovative research will expand our understanding of how regulatory B cells could be modulated to control infections, ameliorate canine allergy and dampen autoimmune diseases like lupus and thyroid disease, and thus may also identify targets for much-needed new therapies for dogs.

AGSDCF Purpose

agsdcf_logo_smallThe American German Shepherd Dog Charitable Foundation, Inc. is a non-profit organization devoted to funding research projects that improve the health of the German Shepherd Dog.

We are grateful to the special dogs who have given their hearts and souls to make our daily lives happier. They ask nothing more than to be loved, fed, and their health needs met.

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