Lymphoma is extremely radiosensitive, however, incorporating full and half-body
radiation therapy has demonstrated a quid pro quo effect between treatment-related toxicities
and tumor control. In human medicine, this approach has been abandoned for advanced IFRT
techniques utilizing advanced radiotherapy systems designed to kill residual disease while
sparing normal tissues. As the technology becomes available in veterinary medicine, this
treatment capability will also become available; however, there are no studies in the veterinary
literature specifically interrogating this strategy. While demonstrable benefit is the ultimate
clinical endpoint, it is critical to ensure safe implementation of IFRT for use in canine patients.
To test feasibility and safety, we propose a phase I study in which patients with advanced
stage lymphoma will be treated with IFRT using helical tomotherapy. Canine patients
identified will be treated with our current standard of care, a 19 week multi-drug chemotherapy
protocol. Upon completion, they will be anesthetized to undergo CT examination for radiation
therapy planning. Enlarged lymph nodes and the spleen and liver will be contoured as targets
and treated to a predetermined dose level. Patients will be subjected to rigorous evaluation at
each treatment and at one month intervals for dose limiting toxicities and/or adverse events.


AGSDCF Purpose

agsdcf_logo_smallThe American German Shepherd Dog Charitable Foundation, Inc. is a non-profit organization devoted to funding research projects that improve the health of the German Shepherd Dog.

We are grateful to the special dogs who have given their hearts and souls to make our daily lives happier. They ask nothing more than to be loved, fed, and their health needs met.

Your donations to this Foundation will help make future generations healthier and happier.



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